MovDisordV3, Main, Exploration, bibRecord, 002B17

Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease

Identifieur interne : 002B17 ( Main/Exploration ); précédent : 002B16; suivant : 002B18

Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease

Auteurs : Yu-Wen Huang [Taïwan] ; Jiann-Shing Jeng [Taïwan] ; Chung-Fen Tsai [Taïwan] ; Li-Ling Chen [Taïwan] ; Ruey-Meei Wu [Taïwan]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-03-15.

RBID : ISTEX:A062C5BFF68F1A6491655885B20966AFEA92A697

Descripteurs français

Pascal (Inist)
- Dopplérométrie, Locus niger, Mésencéphale, Parkinson maladie, Système nerveux pathologie.
Wicri :
- geographic : Taïwan.

English descriptors

KwdEn :
- Aged, Cohort Studies, Demography, Doppler ultrasound study, Female, Humans, Locus niger, Male, Mesencephalon (physiopathology), Mesencephalon (ultrasonography), Midbrain, Middle Aged, Nervous system diseases, Observer Variation, Parkinson Disease (epidemiology), Parkinson Disease (physiopathology), Parkinson Disease (ultrasonography), Parkinson disease, Parkinson's disease, Severity of Illness Index, Substantia Nigra (physiopathology), Substantia Nigra (ultrasonography), Taiwan (epidemiology), Taiwanese, Ultrasonography, Doppler, Transcranial (methods), echogenicity, midbrain, substantia nigra, transcranial doppler image.
MESH :
- geographic , epidemiology : Taiwan.
- epidemiology : Parkinson Disease.
- methods : Ultrasonography, Doppler, Transcranial.
- physiopathology : Mesencephalon, Parkinson Disease, Substantia Nigra.
- ultrasonography : Mesencephalon, Parkinson Disease, Substantia Nigra.
- Aged, Cohort Studies, Demography, Female, Humans, Male, Middle Aged, Observer Variation, Severity of Illness Index.

Abstract

Transcranial Doppler imaging (TCDI) has been used as a noninvasive diagnostic tool to differentiate Parkinson's disease (PD) from atypical parkinsonism by detecting hyperechogenicity in the substantia nigra (SN). To our knowledge, no TCDI data are available for Asian populations, and TCDI sensitivity is uncertain across populations. Early‐onset PD (EOPD) represents a specific PD subtype based on clinical features and pathogenic mechanisms. It is not known if EOPD patients have abnormal echogenicity in SN comparable to late‐onset PD (LOPD) patients. We assessed the area of SN hyperechogenicity (hyper‐SN) and a ratio of hyper‐SN over ipsilateral midbrain (S/M ratio) with TCDI in 164 healthy Taiwanese, 40 EOPD patients, and 40 LOPD patients. The upper 95th percentile values for hyper‐SN and S/M ratio were 0.20 cm2 and 0.07. Our results indicate that S/M ratio is a more sensitive measure than hyper‐SN in diagnosing PD. Approximately 92.5% of the LOPD patients and 57.5% of the EOPD patients had S/M ratios ≥ 0.07. Enlarged hyperechogenicity of SN is a common finding in LOPD, but not in EOPD. Iron‐independent mechanisms of SN cell degeneration in EOPD distinct from that in LOPD might contribute to the sonographic findings. © 2007 Movement Disorder Society

Url:

https://api.istex.fr/document/A062C5BFF68F1A6491655885B20966AFEA92A697/fulltext/pdf

DOI: 10.1002/mds.21372

Affiliations:

Taïwan

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<front><div type="abstract" xml:lang="en">Transcranial Doppler imaging (TCDI) has been used as a noninvasive diagnostic tool to differentiate Parkinson's disease (PD) from atypical parkinsonism by detecting hyperechogenicity in the substantia nigra (SN). To our knowledge, no TCDI data are available for Asian populations, and TCDI sensitivity is uncertain across populations. Early‐onset PD (EOPD) represents a specific PD subtype based on clinical features and pathogenic mechanisms. It is not known if EOPD patients have abnormal echogenicity in SN comparable to late‐onset PD (LOPD) patients. We assessed the area of SN hyperechogenicity (hyper‐SN) and a ratio of hyper‐SN over ipsilateral midbrain (S/M ratio) with TCDI in 164 healthy Taiwanese, 40 EOPD patients, and 40 LOPD patients. The upper 95th percentile values for hyper‐SN and S/M ratio were 0.20 cm2 and 0.07. Our results indicate that S/M ratio is a more sensitive measure than hyper‐SN in diagnosing PD. Approximately 92.5% of the LOPD patients and 57.5% of the EOPD patients had S/M ratios ≥ 0.07. Enlarged hyperechogenicity of SN is a common finding in LOPD, but not in EOPD. Iron‐independent mechanisms of SN cell degeneration in EOPD distinct from that in LOPD might contribute to the sonographic findings. © 2007 Movement Disorder Society</div>
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Movement Disorders (revue)

Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease

Transcranial imaging of substantia nigra hyperechogenicity in a Taiwanese cohort of Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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